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Creators/Authors contains: "Ryan, Lucas S."

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  1. ; ; ; ; ; (, ACS Chemical Biology)
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  2. ; ; (, Results in Chemistry)
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  3. ; ; ; ; ; (, ACS Sensors)
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  4. ; ; ; ; ; ; (, ACS Sensors)
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  5. ; (, Angewandte Chemie International Edition)
  6. ; ; ; ; ; ; ; ; (, Angewandte Chemie International Edition)
    Abstract Azanone (HNO) is a reactive nitrogen species with pronounced biological activity and high therapeutic potential for cardiovascular dysfunction. A critical barrier to understanding the biology of HNO and furthering clinical development is the quantification and real‐time monitoring of its delivery in living systems. Herein, we describe the design and synthesis of the first chemiluminescent probe for HNO,HNOCL‐1, which can detect HNO generated from concentrations of Angeli's salt as low as 138 nmwith high selectivity based on the reaction with a phosphine group to form a self‐cleavable azaylide intermediate. We have capitalized on this high sensitivity to develop a generalizable kinetics‐based approach, which provides real‐time quantitative measurements of HNO concentration at the picomolar level.HNOCL‐1can monitor dynamics of HNO delivery in living cells and tissues, demonstrating the versatility of this method for tracking HNO in living systems. 
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